Welcome
Welcome to Zafgen Inc.
At Zafgen, we are dedicated to developing novel therapeutics to treat obesity, one of the most critical and widespread health issues, affecting more than 400 million people worldwide. Rates of obesity in developing countries have tripled in the last 20 years, and American obesity rates are the highest in the world:
- 64 percent of United States adults are overweight or obese
- In 2007, all but one state had a prevalence of obesity higher than 20 percent
- According to the Centers for Disease Control, about one-third of American children and adolescents are overweight or obese
Zafgen is continuing to explore these remarkable insights and their potential application to a breakthrough treatment for obesity and associated co-morbidities. Substantial proof-of-concept data has been demonstrated in recognized, gold-standard animal models of obesity, and our lead molecules are currently being advanced toward clinical testing.
Zafgen’s groundbreaking approach targets obesity at its biological foundation by safely manipulating and restoring sensitivity of the fat tissue to natural control mechanisms, driving the loss of fat and a return to a more healthy body weight. For more information regarding Zafgen's groundbreaking technology, click here.
Science
Zafgen is a biopharmaceutical company dedicated to developing innovative obesity therapeutics that directly target and shrink fat tissue by helping the body to reestablish a proper balance of fat metabolism.
The Zafgen Team
A growing body of research demonstrates that the nature of adipose tissue, or fat cells, is a significant determinant of obesity. Variations in this tissue—how active or “hungry” it is—affect how much it grows or shrinks in response to dietary intake, and thus whether or not an individual maintains a normal weight or becomes obese.
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