Our Science & Approach

Zafgen has undertaken years of research to characterize the MetAP2 pathway and its effects in various bodily systems.

The Science & Promise of MetAP2 Inhibition

PUBLICATIONS & POSTERS

Prader-Willi Syndrome

poster:
The Novel MetAP2 inhibitor, ZGN-1258, Reduces Body Weight and Food Intake in Mouse Models of Obesity Foundation for Prader-Willi Research 2018 Symposium & Family Conference, October 2018
poster:
ZGN-1258: A Novel Potent MetAP2 Inhibitor With Reduced Risk of Coagulopathy Foundation for Prader-Willi Research 2018 Symposium & Family Conference, October 2018
VIEW All Prader-Willi Syndrome Publications & Posters

Liver-directed Candidate

poster:
Methionine Aminopeptidase 2 Inhibition Attenuates Liver Pathology in Mouse Model of NASH American Association for The Study of Liver Diseases, October 2017, Poster 2054
VIEW All Liver-directed Candidate Publications & Posters

General MetAP2

poster:
Pharmacologic Inhibition of MetAP2 Increases Mitochondrial Number and Activity in Skeletal Muscle Keystone Symposia on Mitochondrial Biology in Heart and Skeletal Muscle, January 2019, Poster 2032
poster:
VIEW All General MetAP2 Publications & Posters